Complex Endometrial Hyperplasia

The excessive proliferation of the cells of the endometrium or inner lining of uterus is called endometrial hyperplasia. Higher level of estrogen combined with lower levels of progesterone leads to this proliferation. Women with endometrial hyperplasia should be closely monitored for the development and co-existence of endometrial cancer.



Endometrial Hyperplasia is a physiological response of the endometrium to the actions of the hormone estrogen. They may be classified as

  • simple without nuclear atypia
  • complex without atypia
  • simple atypical hyperplasia
  • Complex atypical hyperplasia.


They are diagnosed using Endometrial Biopsy or evaluating curettage sample or hysterectomy specimen. An abnormal uterine bleeding or the presence of atypical glandular cells during a Pap smear may suggest testing for Endometrial Hyperplasia.


Treatment for endometrial Hyperplasia varies from individual to individual. The possible treatments are

  • Hormonal Therapy (using cyclic or continuous progestin)
  • Hysterectomy

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